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bioRxiv · 10.1101/635235

Mouse IgG2a antibodies specific for the commensal Streptococcus mitis show stronger cross-reactivity with Streptococcus pneumoniae than IgG1 antibodies

Shekhar, S.·Khan, R.·Khan, A. U. R.·Petersen, F. C.
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Abstract

Here we show that mouse IgG2a and IgG1 antibodies specific for the commensal Streptococcus mitis cross-react with the pathogen Streptococcus pneumoniae, although the cross-reactivity conferred by IgG2a is stronger than IgG1 antibodies. These findings may have implications for designing S. mitis-based vaccines against pneumococcal infections.

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Shekhar, S., Khan, R., Khan, A. U. R., Petersen, F. C.. 2019-05-10. Mouse IgG2a antibodies specific for the commensal Streptococcus mitis show stronger cross-reactivity with Streptococcus pneumoniae than IgG1 antibodies. https://doi.org/10.1101/635235

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