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bioRxiv · 10.1101/630012

Acquisition of cross-resistance to bedaquiline and clofazimine following treatment for tuberculosis in Pakistan

Ghodousi, A.·Rizvi, A. H.·Baloch, A. Q.·Ghafoor, A.·Khanzada, F. M.·Qadir, M.·Borroni, E.·Trovato, A.·Tahseen, S.·Cirillo, D. M.
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Abstract

We report on the first six cases of acquired resistance to bedaquiline in Pakistan. Seventy sequential culture isolates from 30 drug-resistant tuberculosis patients on bedaquiline-containing regimen were tested for minimum inhibitory concentration (MIC) and whole genome sequencing. An increase in MICs associated with cross-resistance to clofazimine and appearance of specific mutations was documented in six cases. The study underlines that appropriate monitoring is mandatory for the introduction of new drugs.

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Ghodousi, A., Rizvi, A. H., Baloch, A. Q., Ghafoor, A., Khanzada, F. M., Qadir, M., Borroni, E., Trovato, A., Tahseen, S., Cirillo, D. M.. 2019-05-07. Acquisition of cross-resistance to bedaquiline and clofazimine following treatment for tuberculosis in Pakistan. https://doi.org/10.1101/630012

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