Reassessing the Evidence for Universal School-age Bacillus Calmette Guerin (BCG) Vaccination in England and Wales

Abstract

BackgroundIn 2005, England and Wales switched from universal BCG vaccination against tuberculosis (TB) disease for school-age children to targeted vaccination of neonates. We assessed the quantitative evidence that informed this policy change.\n\nMethodsWe recreated a previous approach for estimating the impact of ending the BCG schools scheme in England and Wales, updating the model with parameter uncertainty. We investigated scenarios considered by the UKs Joint Committee on Vaccination and Immunisation, and explored new approaches using notification data. We estimated the number of vaccines needed to prevent a single notification, and the average annual additional notifications caused by ending the BCG schools scheme.\n\nResultsWe found a 1.9% annual decrease in TB incidence rates best matched notification data. We estimate that 1600 (2.5-97.5% Quantiles (Q): 1300 - 2100) vaccines would have been required to prevent a single notification in 2004. If the scheme had ended in 2001, 302 (2.5-97.5% Q: 238 - 369) additional annual notifications would have occurred compared to if the scheme had continued. If the scheme ended in 2016, 120 (2.5-97.5% Q: 88 - 155) additional annual notifications would have occurred.\n\nConclusionsOur estimates of the impact of ending the BCG schools scheme were highly sensitive to the annual decrease in incidence rates. The impact of ending the BCG schools scheme was found to be greater than previously thought when parameter values were updated and notification data were used. Our results highlight the importance of including uncertainty when forecasting the impact of changes in vaccination policy.\n\nWhat is already known on this subjectO_LITargeted Bacillus Calmette Guerin (BCG) vaccination against TB is recommended in low incidence countries over universal vaccination.\nC_LIO_LIThe impact of replacing universal BCG vaccination in England and Wales with a targeted programme in 2005 was assessed under the assumption of static declines in TB rates.\nC_LIO_LIThe BCG Guerin vaccine was shown to be effective in the UK born in England, regardless of the age at which it was given. School-age vaccination maybe more beneficial in this population than in other settings.\nC_LI\n\nWhat this study addsO_LIUsing notification data from England and Wales from 1973 to 2015, we estimate that the ending the BCG schools scheme likely resulted in more additional cases than was predicted.\nC_LIO_LIThe inclusion of parameter uncertainty, and measurement error, allowed the uncertainty in the final estimates to be presented. Previously published estimates may have been spuriously precise.\nC_LIO_LIThis study highlights the need for a more detailed evaluation of the 2005 change in BCG policy. In particular, the impact of including the introduction of targeted neonatal vaccination and capturing the long term, indirect, effects needs further study.\nC_LI