Preparation of PLGA Nanoparticles Encapsulated with Fluorescent Probe Coumarin-6

Smith, J.; Purr, E.

doi:10.1101/614875

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bioRxiv · 10.1101/614875

Preparation of PLGA Nanoparticles Encapsulated with Fluorescent Probe Coumarin-6

Smith, J.·Purr, E.

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Abstract

In this report, we provided a novel platform to prepare fluorescent probe coumarin-6 nanoparticles by using biodegradable material polylactic acid-glycolic acid copolymer (PLGA) as material. The coumarin-6-PLGA nanoparticles were prepared by double emulsion and solvent evaporation. The encapsulation efficiency and releasing kinetics were also investigated. Results indicate that the encapsulation efficiency of coumarin-6 nanoparticles was 51.6%, the utilization rate was 81.9%, the average particle size was 135 nm, and the leakage rate of coumarin-6 in vitro was lower than 72 h. 2%. Our experimental results provide evidence that PLGA nanoparticles can effectively encapsulate fluorescent probe Coumarin-6 and release the probe in a controlled manner.

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Smith, J., Purr, E.. 2019-04-23. Preparation of PLGA Nanoparticles Encapsulated with Fluorescent Probe Coumarin-6. https://doi.org/10.1101/614875

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