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bioRxiv · 10.1101/612754

Maternal antibodies provide partial protection from postnatal Zika viremia in nonhuman primates

Abstract

Zika virus (ZIKV) will remain a public health threat until effective vaccines and therapeutics are made available in the hardest hit areas of the world. Recent data in a nonhuman primate model showed that infants postnatally infected with ZIKV were acutely susceptible to high viremia and neurological damage, suggesting the window of vulnerability extends beyond gestation. We addressed the susceptibility of two infant rhesus macaques born healthy to dams infected with Zika virus during pregnancy. Passively acquired neutralizing antibody titers dropped below detection limits between 2 and 3 months of age, while binding, possibly non-neutralizing antibodies remained detectable until viral infection at 5 months of age. Post-infection acute serum viremia was substantially reduced relative to adults infected with the same dose of the same stock of a Brazilian isolate of ZIKV (n=11 pregnant females) and another stock of the same isolate (n=4 males and 4 non-pregnant females). Virus was never detected in cerebrospinal fluid nor in neural tissues at necropsy two weeks after infection, suggesting reduced viral burden relative to adults and published data from infants. However, viral RNA was detected in lymph nodes, confirming some tissue dissemination. Though protection was not absolute, our data suggest infants born healthy to infected mothers may harbor a modest but important level of protection from postnatally acquired ZIKV for several months after birth, an encouraging result given the potentially severe infection outcomes of this population.

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BibTeXRIS

Maness, N., Schouest, B., Singapuri, A., Dennis, M., Gilbert, M., Bohm, R., Schiro, F., Aye, P., Baker, K., Van Rompay, K., Lackner, A., Bonaldo, M., Blair, R., Permar, S., Coffey, L., Panganiban, A., Magnani, D.. 2019-04-18. Maternal antibodies provide partial protection from postnatal Zika viremia in nonhuman primates. https://doi.org/10.1101/612754

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