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bioRxiv · 10.1101/610774

Protein-protein interaction network topology as a measure of bacterial plasmid-chromosome co-evolution

Tran, N. T. H.·Decano, A. G.·Downing, T.·Rahm, A. D.
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Abstract

In this work, we investigate the evolvability of plasmids by examining the topology of plasmid-chromosome gene interactions in Escherichia coli ST131. We discover a convergence of the ratio of non-trivial loops per protein-protein interaction, which allows us to introduce a new invariant of bacterial PPINs: the indirect connectivity value.

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Tran, N. T. H., Decano, A. G., Downing, T., Rahm, A. D.. 2019-04-16. Protein-protein interaction network topology as a measure of bacterial plasmid-chromosome co-evolution. https://doi.org/10.1101/610774

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