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bioRxiv · 10.1101/600163

Associatively-mediated suppression of corticospinal excitability: A transcranial magnetic stimulation (TMS) study

Abstract

Response inhibition--the suppression of prepotent behaviours when they are inappropriate-- has been thought to rely on executive control. Against this received wisdom, it has been argued that external cues repeatedly associated with response inhibition can come to trigger response inhibition automatically without top-down command. The current project endeavoured to provide evidence for associatively-mediated motor inhibition. We tested the hypothesis that stop-associated stimuli can, in a bottom-up fashion, directly activate inhibitory mechanisms in the motor cortex. Human subjects were first trained on a stop-signal task. Once trained, the subjects received transcranial magnetic stimulation applied over their primary motor cortex during passive observation of either the stop signal (i.e. without any need to stop a response) or an equally familiar control stimulus never associated with stopping. Analysis of motor-evoked potentials showed that corticospinal excitability was reduced during exposure to the stop signal, which likely involved stimulus-driven activation of intracortical GABAergic interneurons. This result offers evidence for the argument that, through associative learning, stop-associated stimuli can engage local inhibitory processes at the level of the motor cortex.

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BibTeXRIS

Seet, M. S., Livesey, E. J., Harris, J. A.. 2019-04-05. Associatively-mediated suppression of corticospinal excitability: A transcranial magnetic stimulation (TMS) study. https://doi.org/10.1101/600163

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