Unique Neurophysiological Vulnerability of Visual Attention Networks to Acute Inflammation

Balter, L. J.; Bosch, J. A.; Aldred, S.; Drayson, M. T.; Veldhuijzen van Zanten, J. J.; Higgs, S.; Raymond, J. E.; Mazaheri, A.

doi:10.1101/599159

bioRxiv · 10.1101/599159

Unique Neurophysiological Vulnerability of Visual Attention Networks to Acute Inflammation

Balter, L. J.·Bosch, J. A.·Aldred, S.·Drayson, M. T.·Veldhuijzen van Zanten, J. J.·Higgs, S.·Raymond, J. E.·Mazaheri, A.

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Abstract

Illness is often accompanied by perceived cognitive sluggishness, a symptom that may stem from immune system activation. The current study used electroencephalography (EEG) to assess how inflammation affected three different distinct attentional processes: alerting, orienting and executive control. In a double-blinded placebo-controlled within-subjects design (20 healthy males, mean age = 24.5, SD = 3.4), Salmonella typhoid vaccination (0.025 mg; Typhim Vi, SanofiPasteur) was used to induce transient mild inflammation, while a saline injection served as a placebo-control. Participants completed the Attention Network Test with concurrent EEG recorded six hours post-injection. Analyses focused on behavioral task performance and on modulation of oscillatory EEG activity in the alpha band (9-12 Hz) for alerting as well as orienting attention and frontal theta band (4-8 Hz) for executive control. Vaccination induced mild systemic inflammation, as assessed by interleukin-6 (IL-6) levels. While no behavioral task performance differences between the inflammation and placebo condition were evident, inflammation caused significant alterations to task-related brain activity. Specifically, inflammation produced greater cue-induced suppression of alpha power in the alerting aspect of attention while individual variation in the inflammatory response was significantly correlated with the degree of alpha power suppression. Notably, inflammation did not affect orienting (i.e., alpha lateralization) or executive control (i.e., frontal theta activity). These results reveal a unique neurophysiological vulnerability to acute mild inflammation of the neural network that underpins attentional alerting functions. Observed in the absence of performance decrements, these novel findings suggest that acute inflammation requires individuals to exert greater cognitive effort when preparing for a task in order to maintain adequate behavioral performance.\n\nHighlights O_LITyphoid vaccination induced a transient mild inflammatory state\nC_LIO_LIMild inflammation alters neurophysiological process associated with attention\nC_LIO_LIMild inflammation selectively increased alerting-related alpha suppression while behavior was unaffected\nC_LIO_LIA greater inflammatory response was correlated with more alpha suppression\nC_LI

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Balter, L. J., Bosch, J. A., Aldred, S., Drayson, M. T., Veldhuijzen van Zanten, J. J., Higgs, S., Raymond, J. E., Mazaheri, A.. 2019-04-04. Unique Neurophysiological Vulnerability of Visual Attention Networks to Acute Inflammation. https://doi.org/10.1101/599159

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