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bioRxiv · 10.1101/597765

New β-Lactamase Inhibitors Nacubactam and Zidebactam Improve the In Vitro Activity of β-Lactam Antibiotics Against Mycobacterium abscessus Complex Clinical Isolates

Kaushik, A.·Ammerman, N.·Parrish, N. M.·Nuermberger, E.
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Abstract

The new diazabicyclooctane-based {beta}-lactamase inhibitors avibactam and relebactam improve the in vitro activity of {beta}-lactam antibiotics against Mycobacterium abscessus complex (MABC). Here, we evaluated the in vitro activity of two newer diazabicyclooctane-based {beta}-lactamase inhibitors in clinical development, nacubactam and zidebactam, with {beta}-lactams against clinical isolates of MABC. Both inhibitors lowered the MICs of their partner {beta}-lactams, meropenem (eight-fold) and cefepime (two-fold), and those of other {beta}-lactams, similar to prior results with avibactam and relebactam.

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Kaushik, A., Ammerman, N., Parrish, N. M., Nuermberger, E.. 2019-04-04. New β-Lactamase Inhibitors Nacubactam and Zidebactam Improve the In Vitro Activity of β-Lactam Antibiotics Against Mycobacterium abscessus Complex Clinical Isolates. https://doi.org/10.1101/597765

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