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bioRxiv · 10.1101/596676

Lamina-specific neuronal properties promote robust, stable signal propagation in feedforward networks

Abstract

Feedforward networks (FFN) are ubiquitous structures in neural systems and have been studied to understand mechanisms of reliable signal and information transmission. In many FFNs, neurons in one layer have intrinsic properties that are distinct from those in their pre-/postsynaptic layers, but how this affects network-level information processing remains unexplored. Here we show that layer-to-layer heterogeneity arising from lamina-specific cellular properties facilitates signal and information transmission in FFNs. Specifically, we found that signal transformations, made by neighboring layers of neurons on an input-driven spike signal, are complementary to each other. This mechanism boosts information transfer carried by a propagating spike signal, and thereby supports reliable spike signal and information transmission in a deep FFN. Our study suggests that distinct cell types in neural circuits have complementary computational functions and facilitate information processing on the whole.\n\nSignificance StatementNeural systems have many cell types that differ in properties such as size, shape, cellular mechanisms, etc. Furthermore, neurons often propagate signals to other neurons that have properties very different from their own. We investigated what this phenomenon implies in neural information processing by using computational network models, inspired by a recent experimental study on the olfactory neural pathway of fruit flies. We found that different types of neurons can perform complementary functions in a network, which boosts information transfer on the whole and supports robust, stable signal propagation in a \"deep\" network with many layers. Our study demonstrates that diverse cell types with different intrinsic properties are crucial for optimal signal and information transfer in neural networks.

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BibTeXRIS

Han, D., De Schutter, E., Hong, S.. 2019-04-04. Lamina-specific neuronal properties promote robust, stable signal propagation in feedforward networks. https://doi.org/10.1101/596676

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