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bioRxiv · 10.1101/588350

Prenatal Exposure to Environmental Chemicals Modulates Serum Phospholipids in Newborn Infants, Increasing Later Risk of Type 1 Diabetes

McGlinchey, A.·Sinioja, T.·Lamichhane, S.·Bodin, J.·Siljander, H.·Geng, D.·Carlsson, C.·Duberg, D.·Ilonen, J.·Virtanen, S. M.·Dirven, H.·Bentsen, H. F.·Zimmer, K.·Nygaard, U. C.·Oresic, M.·Knip, M.·Hyotylainen, T.
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Abstract

In the last decade, increasing incidence of type 1 diabetes (T1D) stabilized in Finland, a phenomenon that coincides with tighter regulation of perfluoroalkyl substances (PFAS). Here, we quantified PFAS to examine their effects, during pregnancy, on lipid and immune-related markers of T1D risk in children. In a mother-infant cohort (264 dyads), high PFAS exposure during pregnancy associated with decreased cord serum phospholipids and progression to T1D-associated islet autoantibodies in the offspring. This PFAS-lipid association appears exacerbated by increased human leukocyte antigen-conferred risk of T1D in infants. Exposure to a single PFAS compound or a mixture of organic pollutants in non-obese diabetic mice resulted in a lipid profile characterized by a similar decrease in phospholipids, a marked increase of lithocholic acid, and accelerated insulitis. Our findings suggest that PFAS exposure during pregnancy contributes to risk and pathogenesis of T1D in offspring.

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McGlinchey, A., Sinioja, T., Lamichhane, S., Bodin, J., Siljander, H., Geng, D., Carlsson, C., Duberg, D., Ilonen, J., Virtanen, S. M., Dirven, H., Bentsen, H. F., Zimmer, K., Nygaard, U. C., Oresic, M., Knip, M., Hyotylainen, T.. 2019-03-25. Prenatal Exposure to Environmental Chemicals Modulates Serum Phospholipids in Newborn Infants, Increasing Later Risk of Type 1 Diabetes. https://doi.org/10.1101/588350

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