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bioRxiv · 10.1101/585539

A Long Timescale Stimulus History Effect in the Primary Visual Cortex

Abstract

Responses of neurons in the primary visual cortex (V1) are often understood as encoding the current visual stimulus. Yet, some studies indicate that temporal contingency effects exist in the responses of neurons in early sensory areas. We explored if the recent stimulus history would alter the response of V1 layer 2/3 pyramidal cells in head-fixed awake mice during presentation of sequences of complex images. The activity of individual neurons was sparse, such that either one or none of the images in the sequence typically yielded a strong response. We then substituted an image preceding this primary image in order to determine if responses to the primary image were affected. We found that the amplitude of the neurons response could be significantly altered by substitutions up to five images back from the primary image, even when the substituted image elicited virtually no response by itself. This stimulus history effect was heterogeneous across the population, with some cells showing facilitation and others suppression. For individual cells, the history effect was robust and reproducible across days. Our data show that responses of V1 neurons not only reflect the current stimulus but also encode, through their response amplitude, information about multiple images previously presented as far as 1000 msec in the past. This might enable V1 to retain information about the extended trajectory of past stimuli and perform complex temporal computations that are as of yet not appreciated.

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BibTeXRIS

Kim, H., Homann, J., Tank, D. W., Berry, M. J.. 2019-03-21. A Long Timescale Stimulus History Effect in the Primary Visual Cortex. https://doi.org/10.1101/585539

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