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bioRxiv · 10.1101/584136

A normative study of modified spatial context memory test in middle and older individuals

Kuo, H.-C.·Wang, H.-M.·Huang, Y.-P.·Kuo, H.-Y.
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Abstract

In view of the spatial context memory function of hippocampus complex region, we designed a modified spatial context memory test (SCMT) and try to early identify amnesic mild cognitive impairment.\n\nAll participants with non-dementia were recruited and divided 2 age groups (55-65 years and 66-75 years) and 3 education levels (6-9 years, 10-12 years and more than 12 years). The mini-mental state examination, visual associative memory test, visual construction retention test, and logical memory subtest of the Wechsler memory scale-III were used to evaluate the cognition state of the individuals. Spatial-context memory test version I with combination of a spatial memory paradigm and a real-life event included 3 subtests of navigation, scene-event association and people-object association.\n\nA total of 147 individuals were confirmed to be normal in cognition in the assessment of the neuropsychological test battery. Regardless of age or level of education, there was no significance in perseveration errors and the retrieval of learned-well navigation information. In the Scene-Event Association test, the subjects with a low level of education seemed to have relative difficulty to quickly classify new information and establish the effective cues to retrieval. The subjects with a high level of education, the performance of spatial-context memory were negative correlation to the age. In the People-Object association test, the subjects in all six groups made no perseveration errors, but older subjects required more time to retrieval, and this situation was more prominent in the subjects with high level education.\n\nWe establish a normal age- and education-adjusted SCMT score in the middle and elder individuals.

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Kuo, H.-C., Wang, H.-M., Huang, Y.-P., Kuo, H.-Y.. 2019-03-20. A normative study of modified spatial context memory test in middle and older individuals. https://doi.org/10.1101/584136

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