Sex Solves Haldane’s Dilemma

Abstract

The cumulative reproductive cost of multi-locus selection has been seen as a potentially limiting factor on the rate of adaptive evolution. In this paper, we show that Haldanes arguments for the accumulation of reproductive costs over multiple loci are valid only for a clonally reproducing population of asexual genotypes. We show that a sexually reproducing population avoids this accumulation of costs. Thus, sex removes a perceived reproductive constraint on the rate of adaptive evolution. The significance of our results is twofold. First, the results demonstrate that adaptation based on multiple genes - such as selection acting on the standing genetic variation - does not entail a huge reproductive cost as suggested by Haldane, provided of course that the population is reproducing sexually. Secondly, this reduction in the cost of natural selection provides a simple biological explanation for the advantage of sex. Specifically, Haldanes calculations illustrate the evolutionary disadvantage of asexuality; sexual reproduction frees the population from this disadvantage.