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bioRxiv · 10.1101/573295

Massively Parallel Microwire Arrays Integrated with CMOS chips for Neural Recording

Obaid, A. M.·Hanna, M.-E. S.·Wu, Y.-W.·Kollo, M.·Racz, R. R.·Angle, M. R.·Muller, J.·Brackbill, N.·Wray, W.·Franke, F.·Chichilnisky, E. J.·Hierlemann, A.·Ding, J. B.·Schaefer, A. T.·Melosh, N. A.
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Abstract

Multi-channel electrical recordings of neural activity in the brain is an increasingly powerful method revealing new aspects of neural communication, computation, and prosthetics. However, while planar silicon-based CMOS devices in conventional electronics scale rapidly, neural interface devices have not kept pace. Here, we present a new strategy to interface silicon-based chips with three-dimensional microwire arrays, providing the link between rapidly-developing electronics and high density neural interfaces. The system consists of a bundle of microwires mated to large-scale microelectrode arrays, such as camera chips. This system has excellent recording performance, demonstrated via single unit and local-field potential recordings in isolated retina and in the motor cortex or striatum of awake moving mice. The modular design enables a variety of microwire types and sizes to be integrated with different types of pixel arrays, connecting the rapid progress of commercial multiplexing, digitisation and data acquisition hardware together with a three-dimensional neural interface.

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Obaid, A. M., Hanna, M.-E. S., Wu, Y.-W., Kollo, M., Racz, R. R., Angle, M. R., Muller, J., Brackbill, N., Wray, W., Franke, F., Chichilnisky, E. J., Hierlemann, A., Ding, J. B., Schaefer, A. T., Melosh, N. A.. 2019-03-11. Massively Parallel Microwire Arrays Integrated with CMOS chips for Neural Recording. https://doi.org/10.1101/573295

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