Prevalence and risk factors profile of seropositive Toxoplasmosis gondii infection among apparently immunocompetent Sudanese women

Mustafa, M.; Fathy, F.; Mirghani, A.; Mohamed, M. A.; Muneer, M. S.; Ahmed, A. E.; Ali, M. S.; Omer, R. A.; Siddig, E. E.; Mohamed, N. S.; Abd Elkareem, A. M.

doi:10.1101/572800

bioRxiv · 10.1101/572800

Prevalence and risk factors profile of seropositive Toxoplasmosis gondii infection among apparently immunocompetent Sudanese women

Mustafa, M.·Fathy, F.·Mirghani, A.·Mohamed, M. A.·Muneer, M. S.·Ahmed, A. E.·Ali, M. S.·Omer, R. A.·Siddig, E. E.·Mohamed, N. S.·Abd Elkareem, A. M.

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Abstract

ObjectivesToxoplasma gondii is an opportunistic parasite that cause a clinical manifestation known as toxoplasmosis. We investigated the prevalence and potential risk factors of T. gondii infection among women in Khartoum, Sudan. A sero-parasitological cross-sectional study included 100 women aging between 15-50 years old was conducted in Khartoum, Sudan between January - November 2018. Serum samples were collected and investigated for presence of anti-T. gondii immunoglobulins.\n\nResultsMean age of the women population included was 26.75{+/-}8.25 with a range between 15 and 50 years. Sero-prevalence of T. gondii antibodies was 27% (27/100) with a 95% confidence interval (CI) of 18.6 - 36.8%. Among seropositive population 81% (22/27), 15% (4/27) and 4% (1/27) were seropositive for IgG antibodies, IgM antibodies and both antibodies respectively. Age group 21-30 years old had the highest frequency of detected IgG (10/45) and IgM (3/45). Married women had the highest frequency of detected IgG or IgM, 18/79 and 3/79, respectively. Risk factors analysis showed a total of 37/100 participants were having direct contact with cats and 66/100 have a frequent raw meat consumption, neither direct cats contact nor raw meat consumption had statistically significant association with seropositivity to T. gondii (P. value =0.052 and 0.565, respectively).

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Mustafa, M., Fathy, F., Mirghani, A., Mohamed, M. A., Muneer, M. S., Ahmed, A. E., Ali, M. S., Omer, R. A., Siddig, E. E., Mohamed, N. S., Abd Elkareem, A. M.. 2019-03-10. Prevalence and risk factors profile of seropositive Toxoplasmosis gondii infection among apparently immunocompetent Sudanese women. https://doi.org/10.1101/572800

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