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bioRxiv · 10.1101/569335

Reducing RSV hospitalisation in a lower-income country by vaccinating mothers-to-be and their households

Brand, S. P. C.·Munywoki, P.·Walumbe, D.·Keeling, M. J.·Nokes, D. J.
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Abstract

Respiratory syncytial virus is the leading cause of lower respiratory tract infection among infants. RSV is a priority for vaccine development. In this study, we investigate the potential effectiveness of a two-vaccine strategy aimed at mothers-to-be, thereby boosting maternally acquired antibodies of infants, and their household cohabitants, further cocooning infants against infection. We use a dynamic RSV transmission model which captures transmission both within households and communities, adapted to the changing demographics and RSV seasonality of a low-income country. Model parameters were inferred from past RSV hospitalisations, and forecasts made over a 10-year horizon. We find that a 50% reduction in RSV hospitalisations is possible if the maternal vaccine effectiveness can achieve 75 days of additional protection for newborns combined with a 75% coverage of their birth household co-inhabitants ([~]7.5% population coverage).

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Brand, S. P. C., Munywoki, P., Walumbe, D., Keeling, M. J., Nokes, D. J.. 2019-03-08. Reducing RSV hospitalisation in a lower-income country by vaccinating mothers-to-be and their households. https://doi.org/10.1101/569335

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