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bioRxiv · 10.1101/565531

A Mathematical Model for the Immune-Mediated Theory of Metastasis

Rhodes, A.·Hillen, T.
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Abstract

Accumulating experimental and clinical evidence suggest that the immune response to cancer is not exclusively anti-tumor. Indeed, the pro-tumor roles of the immune system -- as suppliers of growth and pro-angiogenic factors or defenses against cytotoxic immune attacks, for example -- have been long appreciated, but relatively few theoretical works have considered their effects. Inspired by the recently proposed "immune-mediated" theory of metastasis, we develop a mathematical model for tumor-immune interactions at two anatomically distant sites, which includes both anti-and pro-tumor immune effects, and the experimentally observed tumor-induced phenotypic plasticity of immune cells (tumor "education" of the immune cells). Upon confrontation of our model to experimental data, we use it to evaluate the implications of the immune-mediated theory of metastasis. We find that tumor education of immune cells may explain the relatively poor performance of immunotherapies, and that many metastatic phenomena, including metastatic blow-up, dormancy, and metastasis to sites of injury, can be explained by the immune-mediated theory of metastasis. Our results suggest that further work is warranted to fully elucidate the protumor effects of the immune system in metastatic cancer.

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Rhodes, A., Hillen, T.. 2019-03-01. A Mathematical Model for the Immune-Mediated Theory of Metastasis. https://doi.org/10.1101/565531

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