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bioRxiv · 10.1101/564765

Estimation of neural network model parameters from local field potentials (LFPs)

Abstract

Most modeling in systems neuroscience has been descriptive where neural representations, that is, receptive fields, have been found by statistically correlating neural activity to sensory input. In the traditional physics approach to modelling, hypotheses are represented by mechanistic models based on the underlying building blocks of the system, and candidate models are validated by comparing with experiments. Until now validation of mechanistic cortical network models has been based on comparison with neuronal spikes, found from the high-frequency part of extracellular electrical potentials. In this computational study we investigated to what extent the low-frequency part of the signal, the local field potential (LFP), can be used to infer properties of the neuronal network. In particular, we asked the question whether the LFP can be used to accurately estimate synaptic connection weights in the underlying network. We considered the thoroughly analysed Brunel network comprising an excitatory and an inhibitory population of recurrently connected integrate-and-fire (LIF) neurons. This model exhibits a high diversity of spiking network dynamics depending on the values of only three synaptic weight parameters. The LFP generated by the network was computed using a hybrid scheme where spikes computed from the point-neuron network were replayed on biophysically detailed multicompartmental neurons. We assessed how accurately the three model parameters could be estimated from power spectra of stationary background LFP signals by application of convolutional neural nets (CNNs). All network parameters could be very accurately estimated, suggesting that LFPs indeed can be used for network model validation. Significance statementMost of what we have learned about brain networks in vivo have come from the measurement of spikes (action potentials) recorded by extracellular electrodes. The low-frequency part of these signals, the local field potential (LFP), contains unique information about how dendrites in neuronal populations integrate synaptic inputs, but has so far played a lesser role. To investigate whether the LFP can be used to validate network models, we computed LFP signals for a recurrent network model (the Brunel network) for which the ground-truth parameters are known. By application of convolutional neural nets (CNNs) we found that the synaptic weights indeed could be accurately estimated from background LFP signals, suggesting a future key role for LFP in development of network models.

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BibTeXRIS

Skaar, J.-E. W., Stasik, A. J., Hagen, E., Ness, T. V., Einevoll, G. T.. 2019-03-01. Estimation of neural network model parameters from local field potentials (LFPs). https://doi.org/10.1101/564765

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