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bioRxiv · 10.1101/562264

fragilityindex: An R Package for Statistical Fragility Estimates in Biomedicine

Johnson, K. W.·Rappaport, E.·Khader, S.·Glicksberg, B. S.·Dudley, J. T.
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Abstract

Poor reproducibility is a growing crisis in biomedical research. The fragility index was introduced as a convenient measure to estimate how fragile statistical results in clinical trials are to small perturbations in event outcome counts. There is currently no freely available R package to produce this calculation. Furthermore, the original definition of the method is applicable only to 2x2 contingency tables. As such, we developed an R package to calculate fragility index. We have also extended the concept of a statistical fragility index to two of the most commonly used methods in clinical research, survival analysis via weighted log-rank tests and logistic regression, and implemented these technique sin this R package. We describe example applications of these methods to existing publically available datasets. This R package is freely available under the AGPL license on CRAN (https://cran.r-project.org/web/packages/fragilityindex/index.html). The most recent versions may be downloaded and installed via Github (https://github.com/kippjohnson/fragilityindex).

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Johnson, K. W., Rappaport, E., Khader, S., Glicksberg, B. S., Dudley, J. T.. 2019-02-27. fragilityindex: An R Package for Statistical Fragility Estimates in Biomedicine. https://doi.org/10.1101/562264

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