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bioRxiv · 10.1101/553792

Resident memory CD8 T cells persist for years in human small intestine

Bartolome Casado, R.·Landsverk, O. J. B.·Chauhan, S. K.·Richter, L.·Phung, D.·Greiff, V.·Risnes, L. F.·Yao, Y.·Neumann, R. S.·Yaqub, S.·Oyen, O.·Horneland, R.·Aandahl, E. M.·Paulsen, V.·Sollid, L. M.·Qiao, S.-W.·Baekkevold, E. S.·Jahnsen, F. L.
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Abstract

In human small intestine, most CD8 T cells in the lamina propria and epithelium express a resident memory (Trm) phenotype and persist for at least one year in transplanted tissue. Intestinal CD8 Trm cells have a clonally expanded immune repertoire that is stable over time and exhibit enhanced protective capabilities. Graphical abstract O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=199 SRC="FIGDIR/small/553792v1_ufig1.gif" ALT="Figure 1"> View larger version (98K): org.highwire.dtl.DTLVardef@10c19aaorg.highwire.dtl.DTLVardef@168e86forg.highwire.dtl.DTLVardef@73f0f5org.highwire.dtl.DTLVardef@1d08d10_HPS_FORMAT_FIGEXP M_FIG C_FIG HighlightsO_LIThe vast majority of CD8 T cells in the human small intestine are Trm cells C_LIO_LICD8 Trm cells persist for >1 year in transplanted duodenum C_LIO_LIIntraepithelial and lamina propria CD8 Trm cells show highly similar TCR repertoire C_LIO_LIIntestinal CD8 Trm cells efficiently produce cytokines and cytotoxic mediators C_LI

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Bartolome Casado, R., Landsverk, O. J. B., Chauhan, S. K., Richter, L., Phung, D., Greiff, V., Risnes, L. F., Yao, Y., Neumann, R. S., Yaqub, S., Oyen, O., Horneland, R., Aandahl, E. M., Paulsen, V., Sollid, L. M., Qiao, S.-W., Baekkevold, E. S., Jahnsen, F. L.. 2019-02-18. Resident memory CD8 T cells persist for years in human small intestine. https://doi.org/10.1101/553792

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