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bioRxiv · 10.1101/552257

Motor cortex signals corresponding to the two arms are shared across hemispheres, mixed among neurons, yet partitioned within the population response

Abstract

Primary motor cortex (M1) has lateralized outputs, yet M1 neurons can be active during movements of either arm. What is the nature and role of activity in the two hemispheres? When one arm moves, are the contralateral and ipsilateral cortices performing similar or different computations? When both hemispheres are active, how does the brain avoid moving the "wrong" arm? We recorded muscle and neural activity bilaterally while two male monkeys (Macaca mulatta) performed a cycling task with one or the other arm. Neurons in both hemispheres were active during movements of either arm. Yet response patterns were arm-dependent, raising two possibilities. First, the nature of neural signals may differ (e.g., be high versus low-level) depending on whether the ipsilateral or contralateral arm is used. Second, the same population-level signals may be present regardless of the arm being used, but be reflected differently at the individual-neuron level. The data supported this second hypothesis. Muscle activity could be predicted by neural activity in either hemisphere. More broadly, we failed to find signals unique to the hemisphere contralateral to the moving arm. Yet if the same signals are shared across hemispheres, how do they avoid impacting the wrong arm? We found that activity related to the two arms occupied distinct, orthogonal subspaces of population activity. As a consequence, a linear decode of contralateral muscle activity naturally ignored signals related to the ipsilateral arm. Thus, information regarding the two arms is shared across hemispheres and neurons, but partitioned at the population level.

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BibTeXRIS

Ames, K. C., Churchland, M. M.. 2019-02-18. Motor cortex signals corresponding to the two arms are shared across hemispheres, mixed among neurons, yet partitioned within the population response. https://doi.org/10.1101/552257

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