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bioRxiv · 10.1101/547778

Gut microbiota requires vagus nerve integrity to promote depression

Siopi, E.·Saha, S.·Moigneu, C.·Bigot, M.·Lledo, P.-M.
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Abstract

Chronic stress constitutes one of the strongest risk factors for depression and can disrupt various aspects of homeostasis, including gut microbiota composition. We found that stress-induced changes in gut microbiota promote depression and decrease adult hippocampal neurogenesis upon transfer to antibiotic-treated recipient mice. Subdiaphragmatic vagotomy abrogated the microbiota-induced effects on behavior and neurogenesis, suggesting that gut microbiota can influence brain plasticity and behavior through vagal afferents.

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Siopi, E., Saha, S., Moigneu, C., Bigot, M., Lledo, P.-M.. 2019-02-13. Gut microbiota requires vagus nerve integrity to promote depression. https://doi.org/10.1101/547778

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