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bioRxiv · 10.1101/544916

Drying enhances signal intensity for global GC-MS metabolomics.

Liebeke, M.·Puskas, E.
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Abstract

We report here that a straightforward change of standard derivatization procedure for GC-MS metabolomics is leading to a strong increase in metabolite signal intensity. Drying samples between methoxymation and trimethylsilylation significantly increased signals by two-to tenfold in extracts of yeast cells, plant and animal tissue and human urine. This easy step reduces the cost of sample material and the need for expensive new hardware.

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Liebeke, M., Puskas, E.. 2019-02-08. Drying enhances signal intensity for global GC-MS metabolomics.. https://doi.org/10.1101/544916

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