An Objective Technology-based Assessment of Arm and Hand Sensorimotor Disability in Neurological Disorders

Kanzler, C. M.; Rinderknecht, M. D.; Schwarz, A.; Lamers, I.; Gagnon, C.; Held, J.; Feys, P.; Luft, A. R.; Gassert, R.; Lambercy, O.

doi:10.1101/544601

bioRxiv · 10.1101/544601

An Objective Technology-based Assessment of Arm and Hand Sensorimotor Disability in Neurological Disorders

Kanzler, C. M.·Rinderknecht, M. D.·Schwarz, A.·Lamers, I.·Gagnon, C.·Held, J.·Feys, P.·Luft, A. R.·Gassert, R.·Lambercy, O.

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Abstract

BackgroundDetailed assessments of upper limb disability are essential to understand and monitor sensorimotor recovery. Usually, multiple timeconsuming assessments are required to define a holistic sensorimotor profile of proximal (shoulder-elbow) and distal (wrist-hand) impairments and their impact on the capacity to perform activities. We propose and evaluate a novel physiologically-motivated computational framework for objectively assessing sensorimotor profiles in neurological patients using a single, rapid technology-based assessment involving goal-directed arm and hand movements. MethodsThe Virtual Peg Insertion Test (VPIT) was administered to 121 healthy and 80 neurological subjects. The framework provides 25 kinematic and kinetic metrics expected to describe 12 sensorimotor components representative of ataxia and paresis and their influence on task performance, as well as one overall disability measure. The feasibility (protocol duration), structural validity (factor analysis and correlations{rho} between sensorimotor components), concurrent validity (correlation with Action Research Arm Test; ARAT), and discriminant validity (comparing healthy controls and patients, and patients with different disability levels) were evaluated. ResultsThe median VPIT protocol duration was 16.5min in neurological patients. The sensor-based metrics could unambiguously be grouped into 12 mostly independent (median |{rho}|=0.14) components. Ten components showed significant differences between healthy and impaired subjects and nine components indicated clear trends across disability levels, without any ceiling effects. The VPIT overall disability measure and ARAT were moderately correlated ({rho}=-0.53, p<0.001). ConclusionsThis work demonstrates the possibility to rapidly, holistically, and objectively assess proximal and distal sensorimotor impairments and their influence on the capacity to perform activities with a single assessment.

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Kanzler, C. M., Rinderknecht, M. D., Schwarz, A., Lamers, I., Gagnon, C., Held, J., Feys, P., Luft, A. R., Gassert, R., Lambercy, O.. 2019-02-08. An Objective Technology-based Assessment of Arm and Hand Sensorimotor Disability in Neurological Disorders. https://doi.org/10.1101/544601

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