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bioRxiv · 10.1101/542316

Lactate and pyruvate promote cellular stress resistance and longevity through ROS signaling.

Tauffenberger, A.·Fiumelli, H.·Almustafa, S.·Magistretti, P. J.
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Abstract

L-lactate, for long considered a glycolytic end-product, is now recognized as an important energy substrate. Moreover, it appears that its role is not limited to energy production but also as a signal for neuroprotection and synaptic plasticity. Using a model of neuroblastoma cells and the nematode C. elegans we investigated the cellular mechanisms underlying this protective role of L-lactate. We found that L-lactate promotes a mild Reactive Oxygen Species (ROS) induction that translates into activation of antioxidant defenses and pro-survival pathways such as PI3K/AKT and Endoplasmic Reticulum (ER) chaperones. This hormetic mechanism provides protection against oxidative stress in both cells and nematodes. Furthermore, a mild ROS induction by lactate also promotes longevity in C. elegans.

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Tauffenberger, A., Fiumelli, H., Almustafa, S., Magistretti, P. J.. 2019-02-07. Lactate and pyruvate promote cellular stress resistance and longevity through ROS signaling.. https://doi.org/10.1101/542316

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