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bioRxiv · 10.1101/535302

Extremely Drug-Resistant Pseudomonas aeruginosa ST309 Harboring Tandem GES Enzymes: A Newly Emerging Threat in the United States

Khan, A.·Tran, T. T.·Rios, R.·Hanson, B.·Shropshire, W. C.·Sun, Z.·Diaz, L.·Dinh, A. Q.·Wanger, A.·Ostrosky-Zeichner, L.·Palzkill, T.·Arias, C. A.·Miller, W. R.
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Abstract

Two ST309 Pseudomonas aeruginosa clinical isolates resistant to carbapenems and newer {beta}-lactam/{beta}-lactamase inhibitor combinations were found to harbor the extended spectrum beta-lactamases GES 19 and 26 genetically clustered in tandem. The combination of ceftazidime/avibactam plus aztreonam achieved cure in one patient. Phylogenetic analysis suggests that ST309 P. aeruginosa carrying tandem GES are an emerging lineage in the United States.

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Khan, A., Tran, T. T., Rios, R., Hanson, B., Shropshire, W. C., Sun, Z., Diaz, L., Dinh, A. Q., Wanger, A., Ostrosky-Zeichner, L., Palzkill, T., Arias, C. A., Miller, W. R.. 2019-01-30. Extremely Drug-Resistant Pseudomonas aeruginosa ST309 Harboring Tandem GES Enzymes: A Newly Emerging Threat in the United States. https://doi.org/10.1101/535302

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