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bioRxiv · 10.1101/532424

Facilitating open-science with realistic fMRI simulation: validation and application

Ellis, C.·Baldassano, C.·Schapiro, A. C.·Cai, M. B.·Cohen, J.
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Abstract

BackgroundWith advances in methods for collecting and analyzing fMRI data, there is a concurrent need to understand how to reliably evaluate and optimally use these methods. Simulations of fMRI data can aid in both the evaluation of complex designs and the analysis of data. New MethodWe present fmrisim, a new Python package for standardized, realistic simulation of fMRI data. This package is part of BrainIAK: a recently released open-source Python toolbox for advanced neuroimaging analyses. We describe how to use fmrisim to extract noise properties from real fMRI data and then create a synthetic dataset with matched noise properties and a user-specified signal. ResultsWe validate the noise generated by fmrisim to show that it can approximate the noise properties of real data. We further show how fmrisim can help researchers find the optimal design in terms of power. Comparison with other methodsfmrisim ports the functionality of other packages to the Python platform while extending what is available in order to make it seamless to simulate realistic fMRI data. ConclusionsThe fmrisim package holds promise for improving the design of fMRI experiments, which may facilitate both the pre-registration of such experiments as well as the analysis of fMRI data. HighlightsO_LIfmrisim can simulate fMRI data matched to the noise properties of real fMRI. C_LIO_LIThis can help researchers investigate the power of their fMRI designs. C_LIO_LIThis also facilitates open science by making it easy to pre-register analysis pipelines. C_LI

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Ellis, C., Baldassano, C., Schapiro, A. C., Cai, M. B., Cohen, J.. 2019-01-28. Facilitating open-science with realistic fMRI simulation: validation and application. https://doi.org/10.1101/532424

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