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bioRxiv · 10.1101/528869

Cranial Bone Growth in Isolated Sagittal Craniosynostosis Compared to Normal Growth in the First Six Months of Age

Abstract

BackgroundSagittal craniosynostosis (SCS), the most common type of premature perinatal cranial suture fusion, results in abnormal head shape that requires extensive surgery to correct. It is important to find objective and repeatable measures of severity and surgical outcome to examine the effect of timing and technique on different SCS surgeries. The purpose of this study was to develop statistical models of infant (0-6 months old) skull growth in both normative and SCS subjects (prior to surgery). Our goal was to apply these models to the assessment of differences between these two groups in overall post-natal growth patterns and sutural growth rates as a first step to develop methods for predictive models of surgical outcome. Methods and FindingsWe identified 81 patients with isolated, non-syndromic SCS from Seattle Childrens Craniofacial Center patient database who had a pre-operative CT exam before the age of six months. As a control group, we identified 117 CT exams without any craniofacial abnormalities or bone fractures in the same age group. We first created population-level templates from the CT images of the SCS and normal groups. All CT images from both groups, as well as the canonical templates of both cohorts were annotated with anatomical landmarks, which were used in a growth model that predicted the locations of these landmarks at a given age based on each population. Using the template images and the landmark positions predicted by the growth models, we created 3D meshes for each week of age up to six months for both populations. To analyze the growth patterns at the suture sites, we annotated both templates with additional semi-landmarks equally spaced along the metopic, coronal, sagittal and lambdoidal cranial sutures. By transferring these semi-landmarks to meshes produced from the growth model, we measured the displacement of the bone borders and suture closure rates. We found that the growth at the metopic and coronal sutures were more rapid in the SCS cohort compared to the normal cohort. The antero-posterior displacement of the semi-landmarks indicated a more rapid growth in the sagittal plane in the SCS model compared to the normal model as well. ConclusionsStatistical templates and geometric morphometrics are promising tools for understanding the growth patterns in normal and synostotic populations and to produce objective and reproducible measurements of severity and outcome. Our study is the first of its kind to quantify the bone growth for the first six months of life in both normal and sagittal synostosis patients.

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BibTeXRIS

Mercan, E., Hopper, R., Maga, A. M.. 2019-01-24. Cranial Bone Growth in Isolated Sagittal Craniosynostosis Compared to Normal Growth in the First Six Months of Age. https://doi.org/10.1101/528869

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