RNA Polymerase II is involved in 18S and 25S ribosomal RNA transcription, in Candida albicans

Fleischmann, J.; Rocha, M. A.; Hauser, P. V.

doi:10.1101/510156

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bioRxiv · 10.1101/510156

RNA Polymerase II is involved in 18S and 25S ribosomal RNA transcription, in Candida albicans

Fleischmann, J.·Rocha, M. A.·Hauser, P. V.

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Abstract

Introduction Introduction Results Discussion Methods Reference While in eukaryotes three RNA polymerases are involved in ribosome production [1] under usual growth conditions, the 18S and 25S ribosomal RNA (rRNA) components are thought to be exclusively the products of transcription by RNA polymerase I (Pol I) followed by processing [2]. We have observed recently, in Candida albicans during nutritional depletion and with TOR inhibition, the appearance of 18S and 25S rRNA molecules, resisting digestion by a 5'-phosphate-dependent exonuclease, indicating that they were different from the usual processed rRNA transcripts [3]. Candida albicans, a eukaryotic yeast, is a major cause of invasive fungal disease especially in immune compromised patients [4]. ...

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Fleischmann, J., Rocha, M. A., Hauser, P. V.. 2019-01-16. RNA Polymerase II is involved in 18S and 25S ribosomal RNA transcription, in Candida albicans. https://doi.org/10.1101/510156

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