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bioRxiv · 10.1101/507871

iTALK: an R Package to Characterize and Illustrate Intercellular Communication

Wang, Y.·Wang, R.·Zhang, S.·Song, S.·Jiang, C.·Han, G.·Wang, M.·Ajani, J.·Futreal, A.·Wang, L.
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Abstract

Crosstalk between tumor cells and other cells within the tumor microenvironment (TME) plays a crucial role in tumor progression, metastases, and therapy resistance. We present iTALK, a computational approach to characterize and illustrate intercellular communication signals in the multicellular tumor ecosystem using single-cell RNA sequencing data. iTALK can in principle be used to dissect the complexity, diversity, and dynamics of cell-cell communication from a wide range of cellular processes.

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Wang, Y., Wang, R., Zhang, S., Song, S., Jiang, C., Han, G., Wang, M., Ajani, J., Futreal, A., Wang, L.. 2019-01-04. iTALK: an R Package to Characterize and Illustrate Intercellular Communication. https://doi.org/10.1101/507871

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