Coordinated emergence of hippocampal replay and theta sequences during post-natal development

Muessig, L.; Lasek, M.; Varsavsky, I.; Cacucci, F.; Wills, T. J.

doi:10.1101/505636

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bioRxiv · 10.1101/505636

Coordinated emergence of hippocampal replay and theta sequences during post-natal development

Muessig, L.·Lasek, M.·Varsavsky, I.·Cacucci, F.·Wills, T. J.

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Abstract

Hippocampal place cells encode an animals current position in space during exploration[1]. During subsequent sleep, hippocampal network activity recapitulates patterns observed during recent experience: place cells with overlapping spatial firing fields during locomotion show a greater tendency to co-fire ( reactivation) [2] and temporally ordered and compressed sequences of place cell firing observed during wakefulness are reinstated ( replay) [3-5]. Reactivation and replay are thought to be network mechanisms underlying memory consolidation [6-10].

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Muessig, L., Lasek, M., Varsavsky, I., Cacucci, F., Wills, T. J.. 2018-12-26. Coordinated emergence of hippocampal replay and theta sequences during post-natal development. https://doi.org/10.1101/505636

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