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bioRxiv · 10.1101/493908

Physical activity in children and adolescents with Charcot-Marie-Tooth disease: A cross-sectional case-controlled study

Abstract

BackgroundDisability related to the progressive and degenerative neuropathies known as Charcot-Marie-Tooth disease (CMT) affects gait and function, increasing with age and influencing physical activity in adults with CMT. The relationship between disease, ambulatory function and physical activity in children and adolescents with CMT is unknown.\n\nMethodA cross-sectional case-controlled study of 50 children with CMT and age- and gender-matched typically developing (TD) controls [mean age 12.5 (SD 3.9) years]. A 7-day recall questionnaire assessed physical activity; disease severity and gait-related function were measured to explore factors associated with physical activity.\n\nResultsChildren with CMT were less active than TD controls (estimated weekly moderate to vigorous physical activity CMT 283.6 (SD 211.6) mins, TD 318.0 (SD 202.5) mins; p < 0.001). The children with CMT had moderate disability [CMT Pediatric Scale mean score 20 (SD 8) /44] and reduced ambulatory capacity in a six-minute walk test [CMT 485.1 (SD 160.9) metres, TD 639.8 (83.1) metres; p < 0.001]. Physical activity correlated with greater disease severity ({rho} = -0.52, p < 0.001) and six-minute walk distance ({rho} = 0.71, p < 0.001).\n\nConclusionsDisease-related disability affects physical activity and gait-related function in children and adolescents with CMT compared to TD peers. Reduced physical activity adversely affects function across the timespan of childhood and adolescence into adulthood.

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Kennedy, R., Carroll, K., Paterson, K. L., Ryan, M. M., Burns, J., Rose, K., McGinley, J. L.. 2018-12-11. Physical activity in children and adolescents with Charcot-Marie-Tooth disease: A cross-sectional case-controlled study. https://doi.org/10.1101/493908

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