Bayesian inference of chromatin structure ensembles from population Hi-C data

Carstens, S.; Nilges, M.; Habeck, M.

doi:10.1101/493676

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bioRxiv · 10.1101/493676

Bayesian inference of chromatin structure ensembles from population Hi-C data

Carstens, S.·Nilges, M.·Habeck, M.

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Abstract

High-throughput chromosome conformation capture (Hi-C) experiments are typically performed on a large population of cells and therefore only yield average numbers of genomic contacts. Nevertheless population Hi-C data are often interpreted in terms of a single genomic structure, which ignores all cell-to-cell variability. We propose a probabilistic, statistically rigorous method to infer chromatin structure ensembles from population Hi-C data that takes the ensemble nature of the data explicitly into account and allows us to infer the number of structures required to explain the data.

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Carstens, S., Nilges, M., Habeck, M.. 2018-12-12. Bayesian inference of chromatin structure ensembles from population Hi-C data. https://doi.org/10.1101/493676

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