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bioRxiv · 10.1101/485839

Dye-free retinal angiography using blood-oxygenation modulation

MacKenzie, L. E.·Choudhary, T. R.·Fernandez Ramos, J.·Benjamin, N.·Delles, C.·Harvey, A. R.
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Abstract

Fluorescence angiography (FA) is widely used for studying and diagnosing abnormalities in the retinal blood circulation, but has associated risks of nausea, skin irritation, and even death. We describe a new non-invasive angiography technique: Blood Oxygenation Modulation Angiography, in which multispectral imaging of a transient perturbation in blood-oxygen saturation, yields angiography sequences similar to FA, including key features such as sequential filling of choroidal and retinal-vessels, which underpin assessment of circulation health. This is the first non-invasive angiography technique capable of visualizing these circulation features.

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MacKenzie, L. E., Choudhary, T. R., Fernandez Ramos, J., Benjamin, N., Delles, C., Harvey, A. R.. 2018-12-04. Dye-free retinal angiography using blood-oxygenation modulation. https://doi.org/10.1101/485839

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