Carbapenem-resistant Pseudomonas aeruginosa bloodstream infection: in vitro synergy, virulence and clinical outcome

Ramos, J. F.; Cristina Leite, G.; Rizek, C. F.; Rossi, F.; Guimaraes, T.; Sanabani, S. S.; Sara Levin, A.; Rocha, V.; Costa, S. F.

doi:10.1101/480236

bioRxiv · 10.1101/480236

Carbapenem-resistant Pseudomonas aeruginosa bloodstream infection: in vitro synergy, virulence and clinical outcome

Ramos, J. F.·Cristina Leite, G.·Rizek, C. F.·Rossi, F.·Guimaraes, T.·Sanabani, S. S.·Sara Levin, A.·Rocha, V.·Costa, S. F.

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Abstract

In the current study carbapanem-resistant P. aeruginosa bloodstream infection (CRPA-BSI) was associated with high 14-day mortality. Although, highly resistant to meropenem, half of the isolates achieved in vitro synergy with the combination of meropenem with colistin, and the patients that received this combination therapy showed a tendency towards lower mortality. Our strains did not carry exoU gene, on the other hand, patients with CRPA-BSI caused by strains harboring gene lasB evolved more frequent to death.

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Ramos, J. F., Cristina Leite, G., Rizek, C. F., Rossi, F., Guimaraes, T., Sanabani, S. S., Sara Levin, A., Rocha, V., Costa, S. F.. 2018-11-29. Carbapenem-resistant Pseudomonas aeruginosa bloodstream infection: in vitro synergy, virulence and clinical outcome. https://doi.org/10.1101/480236

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