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bioRxiv · 10.1101/479386

Thermopneumatic suction integrated microfluidic blood analysis system

Yang, C.-H.·Hsieh, Y.-L.·Tsou, P.-H.·Li, B.-R.
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Abstract

Blood tests provide crucial diagnostic information regarding several diseases. A key factor that affects the precision and accuracy of blood tests is the interference of red blood cells; however, the conventional methods of blood separation are often complicated and time consuming. In this study, we devised a simple but high-efficiency blood separation system on a self-strained microfluidic device that separates 99.7% of the plasma in only 6 min. Parameters, such as flow rate, design of the filter trench, and the relative positions of the filter trench and channel, were optimized through microscopic monitoring. Moreover, this air-difference-driven device uses a cost-effective and easy-to-use heater strip that creates a low-pressure environment in the microchannel within minutes. With the aforementioned advantages, this blood separation device could be another platform choice for point-of-care testing.

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Yang, C.-H., Hsieh, Y.-L., Tsou, P.-H., Li, B.-R.. 2018-11-26. Thermopneumatic suction integrated microfluidic blood analysis system. https://doi.org/10.1101/479386

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