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bioRxiv · 10.1101/468868

Culling less fit neurons protects against amyloid-β induced brain damage and cognitive and motor decline

Coelho, D. S.·Schwartz, S.·Merino, M. M.·Hauert, B.·Topfel, B.·Tieche, C.·Rhiner, C.·Moreno, E.
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Abstract

Alzheimers disease (AD) is the most common form of dementia, impairing cognitive and motor functions. One of the pathological hallmarks of AD is neuronal loss, which is not reflected in mouse models of AD. Therefore, the role of neuronal death is still uncertain. Here, we used a Drosophila AD model expressing a secreted form of human amyloid-{beta}42 peptide and show that it recapitulates key aspects of AD pathology, including neuronal death and impaired long-term memory. We found that neuronal apoptosis is mediated by cell fitness-driven neuronal culling, which selectively eliminates impaired neurons from brain circuits. We show that removal of less fit neurons delays amyloid-{beta}42-induced brain damage and protects against cognitive and motor decline, suggesting that - contrary to common knowledge - neuronal death may have a beneficial effect in AD.

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Coelho, D. S., Schwartz, S., Merino, M. M., Hauert, B., Topfel, B., Tieche, C., Rhiner, C., Moreno, E.. 2018-11-13. Culling less fit neurons protects against amyloid-β induced brain damage and cognitive and motor decline. https://doi.org/10.1101/468868

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