ENvironmental Dynamics Underlying Responsive Extreme Survivors (ENDURES) of Glioblastoma: a Multi-disciplinary Team-based, Multifactorial Analytical Approach

Johnston, S. K.; Whitmire, P.; Massey, S. C.; Kumthekar, P.; Porter, A. B.; Raghunand, N.; Gonzalez-Cuyar, L. F.; Mrugala, M. M.; Hawkins-Daarud, A.; Jackson, P. R.; Hu, L. S.; Sarkaria, J. N.; Wang, L.; Gatenby, R. A.; Egan, K. M.; Canoll, P.; Swanson, K. R.

doi:10.1101/461236

bioRxiv · 10.1101/461236

ENvironmental Dynamics Underlying Responsive Extreme Survivors (ENDURES) of Glioblastoma: a Multi-disciplinary Team-based, Multifactorial Analytical Approach

Johnston, S. K.·Whitmire, P.·Massey, S. C.·Kumthekar, P.·Porter, A. B.·Raghunand, N.·Gonzalez-Cuyar, L. F.·Mrugala, M. M.·Hawkins-Daarud, A.·Jackson, P. R.·Hu, L. S.·Sarkaria, J. N.·Wang, L.·Gatenby, R. A.·Egan, K. M.·Canoll, P.·Swanson, K. R.

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Abstract

Although glioblastoma is a fatal primary brain cancer with a short median survival of 15 months, a small number of patients survive more than 5 years after diagnosis; they are known as extreme survivors (ES). Due to their rarity, very little is known about what differentiates these outliers from other glioblastoma patients. For the purpose of identifying unknown drivers of extreme survivorship in glioblastoma, we developed the ENDURES consortium (ENvironmental Dynamics Underlying Responsive Extreme Survivors of glioblastoma). This consortium is a multicenter collaborative network of investigators focused on the integration of multiple types of clinical data and the creation of patient-specific models of tumor growth informed by radiographic and histological parameters. Leveraging our combined resources, the goals of the ENDURES consortium are two-fold: (1) to build a curated, searchable, multilayered repository housing clinical and outcome data on a large cohort of ES patients with glioblastoma and (2) to leverage the ENDURES repository for new insights on tumor behavior and novel targets for prolonging survival for all glioblastoma patients. In this article, we review the available literature and discuss what is already known about ES. We then describe the creation of our consortium and some of our preliminary results.\n\nFundingThis review was financially supported by a grant from the James S. McDonnell Foundation\n\nConflicts of InterestThe authors have declared that no conflicts of interest exist.\n\nAuthorshipConceptualized consortium: LW, RG, KME, PC, and KRS. Built consortium: SKJ, PK, NR, JS, KME, PC, and KRS. Wrote the manuscript: SKJ, PW, SCM, PK, AP, and KME. Reviewed and edited the manuscript: LFGC, MMM, AHD, PRJ, and LSH. Contributed to writing, provided feedback, and approved of final manuscript: All authors.\n\nLink to website for ENDUREShttp://mathematicalneurooncology.org/?page_id=2125

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Johnston, S. K., Whitmire, P., Massey, S. C., Kumthekar, P., Porter, A. B., Raghunand, N., Gonzalez-Cuyar, L. F., Mrugala, M. M., Hawkins-Daarud, A., Jackson, P. R., Hu, L. S., Sarkaria, J. N., Wang, L., Gatenby, R. A., Egan, K. M., Canoll, P., Swanson, K. R.. 2018-11-04. ENvironmental Dynamics Underlying Responsive Extreme Survivors (ENDURES) of Glioblastoma: a Multi-disciplinary Team-based, Multifactorial Analytical Approach. https://doi.org/10.1101/461236

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