Bioinorganic Angiogenesis

Maillard, S.; Charbonnier, B.; Sayed, O.; Baradaran, A.; Mangat, H.; Dallison, B.; Zhang, Z.; Zhang, Y. L.; Hussain, S. N. A.; Mayaki, D.; Seitz, H.; Harvey, E.; Gilardino, M.; Gbureck, U.; Makhoul, N.; Barralet, J.

doi:10.1101/455212

bioRxiv · 10.1101/455212

Bioinorganic Angiogenesis

Maillard, S.·Charbonnier, B.·Sayed, O.·Baradaran, A.·Mangat, H.·Dallison, B.·Zhang, Z.·Zhang, Y. L.·Hussain, S. N. A.·Mayaki, D.·Seitz, H.·Harvey, E.·Gilardino, M.·Gbureck, U.·Makhoul, N.·Barralet, J.

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Abstract

Causing a large diameter blood vessel to sprout branches and a capillary network on demand to create a new angiosome is key to harnessing to potential of regenerative medicine and advancing reconstructive surgery. Currently this can only be achieved by connecting a vein graft to an artery by microsurgery, the arteriovenous loop technique (AVL). The arterial blood pressure in the thin-walled vein is thought to drive remodelling to create branches, however the surgical complexity limits the application of the technique. In this study we demonstrate that unexpectedly, a vessel density of luminal branches in excess of that achieved by the surgical AVL approach can be induced simply by placing a vein in contact with a microporous calcium phosphate. Only osteoinductive biomaterials have been reported previously, this is thought to be the first report of an angio-inductive material. Pilot studies indicated that the material type greatly affected the degree of luminal vascularization. Material contact with the vein is not a requirement for luminal angiogenesis of the vein and together these findings point to a bioinorganic effect, wherein the degradation of the material both releases a stimulatory ionic milieu and creates space for the developing angiosome.

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Maillard, S., Charbonnier, B., Sayed, O., Baradaran, A., Mangat, H., Dallison, B., Zhang, Z., Zhang, Y. L., Hussain, S. N. A., Mayaki, D., Seitz, H., Harvey, E., Gilardino, M., Gbureck, U., Makhoul, N., Barralet, J.. 2018-10-29. Bioinorganic Angiogenesis. https://doi.org/10.1101/455212

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