Single neurons in the human entorhinal cortex remap to distinguish individual spatial memories

Qasim, S. E.; Miller, J.; Inman, C. S.; Gross, R.; Willie, J. T.; Lega, B.; Lin, J.-J.; Sharan, A.; Wu, C.; Sperling, M. R.; Sheth, S.; McKhann, G. M.; Smith, E. H.; Schevon, C.; Stein, J.; Jacobs, J.

doi:10.1101/433862

bioRxiv · 10.1101/433862

Single neurons in the human entorhinal cortex remap to distinguish individual spatial memories

Qasim, S. E.·Miller, J.·Inman, C. S.·Gross, R.·Willie, J. T.·Lega, B.·Lin, J.-J.·Sharan, A.·Wu, C.·Sperling, M. R.·Sheth, S.·McKhann, G. M.·Smith, E. H.·Schevon, C.·Stein, J.·Jacobs, J.

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Abstract

The entorhinal cortex (EC) is known to play a key role in both memory and spatial navigation. Despite this overlap in spatial and mnemonic circuits, it is unknown how spatially responsive neurons contribute to our ability to represent and distinguish past experiences. Recording from medial temporal lobe (MTL) neurons in subjects performing cued recall of object-location memories in a virtual-reality environment, we identified \"trace cells\" in the EC that remap their spatial fields to locations subjects were cued to recall on each trial. In addition to shifting its firing field according to the memory cue, this neuronal activity exhibited a firing rate predictive of the cued memorys content. Critically, this memory-specific neuronal activity re-emerged when subjects were cued for recall without entering the environment, indicating that trace-cell memory representations generalized beyond navigation. These findings suggest a general mechanism for memory retrieval via trace-cell activity and remapping in the EC.

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Qasim, S. E., Miller, J., Inman, C. S., Gross, R., Willie, J. T., Lega, B., Lin, J.-J., Sharan, A., Wu, C., Sperling, M. R., Sheth, S., McKhann, G. M., Smith, E. H., Schevon, C., Stein, J., Jacobs, J.. 2018-10-03. Single neurons in the human entorhinal cortex remap to distinguish individual spatial memories. https://doi.org/10.1101/433862

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