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bioRxiv · 10.1101/428623

High diversity, turnover, and structural constraints characterize TCR α and β repertoire selection

Kamga, L.·Gil, A.·Song, I.·Chirravuri, R.·Aslan, N.·Ghersi, D.·Stern, L. J.·Selin, L. K.·Luzuriaga, K.
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Abstract

Recognition modes of individual T-cell receptors (TCR) are well studied, but how TCR repertoires are selected during acute through persistent human virus infections is less clear. Here, we show that persistent EBV-specific clonotypes account for only 9% of unique clonotypes but are highly expanded in acute infectious mononucleosis, and have distinct antigen-specific public features that drive selection into convalescence. The other 91% of highly diverse unique clonotypes disappear and are replaced in convalescence by equally diverse \"de-novo\" clonotypes. These broad fluctuating repertoires lend plasticity to antigen recognition and potentially protect against T-cell clonal loss and viral escape.

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Kamga, L., Gil, A., Song, I., Chirravuri, R., Aslan, N., Ghersi, D., Stern, L. J., Selin, L. K., Luzuriaga, K.. 2018-09-29. High diversity, turnover, and structural constraints characterize TCR α and β repertoire selection. https://doi.org/10.1101/428623

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