Shared and distinct genetic risk factors for childhood onset and adult onset asthma

Abstract

BackgroundChildhood and adult onset asthma differ with respect to severity and co-morbidities. Whether they also differ with respect to genetic risk factors has not been previously investigated.\n\nMethodsWe used data from the UK Biobank to conduct genome-wide association studies (GWASs) in 9,433 childhood onset asthma (onset before age 12) and 21,564 adult onset asthma (onset between ages 26 and 65) cases, each compared to 318,237 non-asthmatic controls (older than age 38), and for age of onset in 37,846 asthma cases. Enrichment studies determined the tissues in which genes at GWAS loci were most highly expressed, and PrediXcan, a transcriptome-wide gene-based test, was used to identify candidate risk genes.\n\nFindingsWe detected 61 independent asthma loci: 23 were childhood onset specific, one was adult onset specific, and 37 were shared. Nineteen loci were associated with age of asthma onset. Genes at the childhood onset loci were most highly expressed in skin, blood and small intestine; genes at the adult onset loci were most highly expressed in lung, blood, small intestine and spleen. PrediXcan identified 113 unique candidate genes at 22 of the 61 GWAS loci.\n\nInterpretationGenetic risk factors for adult onset asthma are largely a subset of the genetic risk for childhood onset asthma but with overall smaller effects, suggesting a greater role for non-genetic risk factors in adult onset asthma. In contrast, the onset of disease in childhood is associated with additional genes with relatively large effect sizes. Combined with gene expression and tissue enrichment patterns, we suggest that the establishment of disease in children is driven more by allergy and epithelial barrier dysfunction whereas the etiology of adult onset asthma is more lung-centered, with immune mediated pathways driving disease progression in both children and adults.\n\nFundingThis work was supported by the National Institutes of Health grants R01 MH107666 and P30 DK20595 to H.K.I., R01 HL129735, R01 HL122712, P01 HL070831, and UG3 OD023282 to C.O.; N.S. was supported by T32 HL007605.