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bioRxiv · 10.1101/425983

Novel 5-Hydroxymethylcytosine Markers for Pancreatic Cancer

Zeng, C.·Zhang, Z.·Wang, J.·Chiu, B. C.-H.·Hou, L.·Zhang, W.
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Abstract

OBJECTIVESRobust biomarkers for pancreatic cancer (PaC) early detection/prognosis are critical for improved patient survival. Our goal was to explore the biomarker potential of 5-hydroxymethylcytosines (5hmC), an epigenetic marker with a distinct role in cancer pathobiology, yet under-investigated due largely to technical constraints.\n\nMETHODSWe used the TAB-Array assay, a state-of-the-art technology to directly profile 5hmC at single base resolution with the Illumina EPIC array (>850,000 CpG sites) in 17 pairs of tumor/adjacent tissue samples from US patients.\n\nRESULTSWe demonstrated distinctive distributions of 5hmC in tissues, and substantial differences between tumor and adjacent tissues, suggesting their diagnostic/prognostic value of for PaC.\n\nCONCLUSIONThis study established the potential of 5hmC as a novel epigenetic biomarker for PaC.

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Zeng, C., Zhang, Z., Wang, J., Chiu, B. C.-H., Hou, L., Zhang, W.. 2018-09-25. Novel 5-Hydroxymethylcytosine Markers for Pancreatic Cancer. https://doi.org/10.1101/425983

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