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bioRxiv · 10.1101/412510

Regulation of Cell-Type-Specific Transcriptomes by miRNA Networks During Human Brain Development

Nowakowski, T. J.·Rani, N.·Golkaram, M.·Zhou, H. R.·Alvarado, B.·Huch, K.·West, J.·Leyrat, A.·Pollen, A. A.·Kriegstein, A. R.·Petzold, L. R.·Kosik, K. S.
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Abstract

MicroRNAs (miRNAs) regulate many cellular events by regulating hundreds of mRNA transcripts. However, it is unclear how miRNA-mRNA interactions are contextualized into the framework of transcriptional heterogeneity among closely related cells of the developing human brain. By combining the multiple complementary approaches, AGO2-HITS-CLIP, single-cell profiling and bipartite network analysis, we show that the miRNA-mRNA network operates as functional modules related to cell-type identities and undergo dynamic transitions during brain development.

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Nowakowski, T. J., Rani, N., Golkaram, M., Zhou, H. R., Alvarado, B., Huch, K., West, J., Leyrat, A., Pollen, A. A., Kriegstein, A. R., Petzold, L. R., Kosik, K. S.. 2018-09-09. Regulation of Cell-Type-Specific Transcriptomes by miRNA Networks During Human Brain Development. https://doi.org/10.1101/412510

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