Emergence and rapid global dissemination of CTX-M-15-associated Klebsiella pneumoniae strain ST307

Wyres, K. L.; Hawkey, J.; Hetland, M. A. K.; Fostervold, A.; Wick, R. R.; Judd, L. M.; Hamidian, M.; Howden, B. P.; Lohr, I. H.; Holt, K. E.

doi:10.1101/352740

bioRxiv · 10.1101/352740

Emergence and rapid global dissemination of CTX-M-15-associated Klebsiella pneumoniae strain ST307

Wyres, K. L.·Hawkey, J.·Hetland, M. A. K.·Fostervold, A.·Wick, R. R.·Judd, L. M.·Hamidian, M.·Howden, B. P.·Lohr, I. H.·Holt, K. E.

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Abstract

Recent reports indicate the emergence of a new carbapenemase producing Klebsiella pneumoniae clone, ST307. Here we show that ST307 emerged in the mid-1990s (nearly 20 years prior to its first report), is already globally distributed and is intimately associated with a conserved plasmid harbouring the blaCTX-M-15 extended-spectrum beta-lactamase (ESBL) gene plus other antimicrobial resistance determinants. Our findings support the need for enhanced surveillance of this widespread ESBL clone in which carbapenem resistance is now emerging.

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Wyres, K. L., Hawkey, J., Hetland, M. A. K., Fostervold, A., Wick, R. R., Judd, L. M., Hamidian, M., Howden, B. P., Lohr, I. H., Holt, K. E.. 2018-06-21. Emergence and rapid global dissemination of CTX-M-15-associated Klebsiella pneumoniae strain ST307. https://doi.org/10.1101/352740

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