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bioRxiv · 10.1101/352641

Liquid biopsy for infectious diseases: Sequencing of cell-free plasma to detect pathogen DNA in patients with invasive fungal disease

Hong, D. K.·Blauwkamp, T. A.·Kertesz, M.·Bercovici, S.·Truong, C.·Banaei, N.
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Abstract

Diagnosis of life-threatening deep-seated infections currently requires invasive sampling of the infected tissue to provide a microbiologic diagnosis. These procedures can lead to high morbidity in patients and add to healthcare costs. Here we describe a novel next-generation sequencing assay that was used to detect pathogen-derived cell-free DNA in peripheral blood of patients with biopsy-proven invasive fungal infections. The non-invasive nature of this approach could provide rapid, actionable treatment information for invasive fungal infections when a biopsy is not possible.

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Hong, D. K., Blauwkamp, T. A., Kertesz, M., Bercovici, S., Truong, C., Banaei, N.. 2018-06-20. Liquid biopsy for infectious diseases: Sequencing of cell-free plasma to detect pathogen DNA in patients with invasive fungal disease. https://doi.org/10.1101/352641

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