Xist lncRNA forms silencing granules that induce heterochromatin formation and repressive complexes recruitment by phase separation

Cerase, A.; Armaos, A.; Cid-Samper, F.; Avner, P.; Tartaglia, G. G.

doi:10.1101/351015

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bioRxiv · 10.1101/351015

Xist lncRNA forms silencing granules that induce heterochromatin formation and repressive complexes recruitment by phase separation

Cerase, A.·Armaos, A.·Cid-Samper, F.·Avner, P.·Tartaglia, G. G.

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Abstract

Main text Main text Microscopy RNA Structure Protein-RNA interactions Granule propensity Material and methods in... References Long non-coding RNAs (lncRNAs) are RNA molecules longer than 200 bases that lack coding potential1,2. They represent a significant portion of the cell transcriptome3 and work as activators or repressors of gene transcription acting on different regulatory mechanisms4-6. Indeed, lncRNAs can act as macro-scaffolds for protein recruitment7-14 and behave as guides and sponges for titrating RNA and proteins, influencing transcription at regulatory regions or triggering transcriptional interfere ...

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Cerase, A., Armaos, A., Cid-Samper, F., Avner, P., Tartaglia, G. G.. 2018-06-20. Xist lncRNA forms silencing granules that induce heterochromatin formation and repressive complexes recruitment by phase separation. https://doi.org/10.1101/351015

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