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bioRxiv · 10.1101/334193

Antimicrobial Activity of Tetrabromobisphenol A (TBBPA) against Staphylococcus aureus Skin Infections

Wang, C.·Ji, F.·Chen, F.·Chen, B.·Zhou, Z.·Li, Z.·Liang, Y.
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Abstract

Tetrabromobisphenol A (TBBPA) is a brominated flame retardant with selective antimicrobial activity against Gram-positive bacteria. We show that TBBPA exerts bactericidal effects by damaging the cell wall and membrane of Staphylococcus aureus (SA) without inducing antimicrobial resistance. In vivo skin infection assays indicate that a low dose of TBBPA could contribute to wound closure and attenuate SA infection and inflammatory infiltration. TBBPA has potential for use as an antimicrobial agent against Gram-positive pathogens.

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Wang, C., Ji, F., Chen, F., Chen, B., Zhou, Z., Li, Z., Liang, Y.. 2018-05-30. Antimicrobial Activity of Tetrabromobisphenol A (TBBPA) against Staphylococcus aureus Skin Infections. https://doi.org/10.1101/334193

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