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bioRxiv · 10.1101/330571

Allostery in oligomeric receptor models

Conradi Smith, G. D.
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Abstract

We show how equilibrium binding curves of receptor heterodimers and homodimers can be expressed as rational polynomial functions of the equilibrium binding curves of the constituent monomers, without approximation and without assuming independence of receptor monomers. Using a distinguished spanning tree construction for reduced graph powers, the method properly accounts for thermodynamic constraints and allosteric coupling between receptor monomers.

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Conradi Smith, G. D.. 2018-05-25. Allostery in oligomeric receptor models. https://doi.org/10.1101/330571

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